Whenever I have talked about the HPV vaccine as an anti-cancer vaccine, I am usually met with at least a modicum of skepticism. For so long, we have associated vaccines as agents to protect us from Acute infectious diseases—small pox, polio, diphtheria, tetanus, measles, among others. Our lifelong experience with vaccines has not allowed us to get our heads around the concept that, for the first time in history, a vaccine has been developed whose primary objective is to stave off cancer.